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ABSTRACT There are some fundamental questions related to Alzheimer’s disease that have not yet been answered satisfactorily. In some cases, the tools were not previously available to answer these questions. This project will investigate the role of brain insulin in Alzheimer’s disease using new state-of-the-art genetically engineered models because it has the potential to change…

ABSTRACT A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the primary cause of brain cell death in Alzheimer’s disease. We have identified an A-beta oligomer-specific targeting site, which exclusively detects A-beta oligomers in the brains…

ABSTRACT One percent of Alzheimer’s disease is the early-onset type that runs in families. Extensive studies of these ultra-rare forms of Alzheimer’s disease have revealed the genes that cause them. On the other hand, the most common forms of Alzheimer’s disease are surprisingly understudied and poorly understood at the level required for therapeutic intervention. However,…