100% committed to ending dementia. For good.

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All in to end Alzheimer disease.

CLEAR is the only Canadian foundation that directs 100% of funds raised to promising scientific research into the cause, prevention, and treatment of Alzheimer disease and other dementias.

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Because it’s clear: the only path to a cure is more research.

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650K+

people living with dementia in Canada

Even more alarmingly, by 2031 this number is expected to exceed 1 million.

40

research projects funded by CLEAR

Each of these projects has contributed to our collective understanding of dementia.

8th

leading cause of death in Canada

Every year, over 6,000 Canadians die from the disease. That’s 16 loved ones lost each day.

$15M+

of funding provided to researchers

We will keep funding promising research until we have the cure the world has been waiting for.

Past & Present Research

The effects of resistance training on myelin and blood-based biomarkers of neuroplasticity in older adults

ABSTRACT We are studying if strength training exercises can reduce myelin loss and preserve cognitive abilities in adults with cognitive impairment due to vascular risk factors (e.g., high blood pressure), also known as vascular cognitive impairment (VCI). Worldwide, VCI is the second most common cause of dementia and it is associated with myelin loss. Myelin…

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The mechanism and significance of the synaptogenic activity of amyloid precursor protein

ABSTRACT Amyloid Precursor Protein (APP) is a cell surface protein that has been mostly studied in the context of Alzheimer’s disease. Much about its normal function remains unknown. APP can cause connections to form between brain cells by an unknown mechanism. We believe this happens through an interaction with synaptic organizing proteins (organizers). This project…

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Neurally-produced estradiol enhances the neuroprotective actions of insulin

ABSTRACT Estradiol enhances insulin production and response in the pancreas. However, the effects of estradiol in the brain have never been confirmed. Yet when expressed together in the hippocampus (a brain structure critically involved in memory), estradiol and insulin promote neuron growth and survival as well as synapse formation and maintenance. Dr. Mehran tested the…

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Non-invasive imaging of Alzheimer Disease biomarkers in the brain and eye

ABSTRACT Age related neurodegenerative diseases such as Alzheimer’s Disease (AD) affect ~500,000 Canadians, and the economic burden of dementia was $15 billion in 2008. Early diagnosis and novel therapies are needed to improve the quality of life of affected individuals, and to reduce costs to the Canadian health care system. However, screening for irreversible hallmarks…

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