100% committed to ending dementia. For good.

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All in to end Alzheimer disease.

CLEAR is the only Canadian foundation that directs 100% of funds raised to promising scientific research into the cause, prevention, and treatment of Alzheimer disease and other dementias.

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Because it’s clear: the only path to a cure is more research.

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650K+

people living with dementia in Canada

Even more alarmingly, by 2031 this number is expected to exceed 1 million.

40

research projects funded by CLEAR

Each of these projects has contributed to our collective understanding of dementia.

8th

leading cause of death in Canada

Every year, over 6,000 Canadians die from the disease. That’s 16 loved ones lost each day.

$15M+

of funding provided to researchers

We will keep funding promising research until we have the cure the world has been waiting for.

Past & Present Research

Preclincal development of a disease modifying small molecule therapy for Alzheimer disease

ABSTRACT No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). The two pathological hallmarks of AD are protein aggregates deposited in the brain that are known as tangles and plaques. These aggregates form from inappropriately modified forms of the microtubule associated protein tau and peptide fragments, known as Aβ…

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Altered glutamate dynamics in a mouse model of Alzheimer’s disease: Novel early biomarkers with therapeutic potential

ABSTRACT Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. With no cure available, it imposes a major burden on society. In AD, a protein called amyloid beta accumulates into plaques in the brain. This event is an early and predictive marker for AD and can be detected up to 20 years before clinical symptoms arise.…

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Are there indicators of Alzheimer’s disease in the eye?: New computational imaging and analysis algorithms

ABSTRACT The goal was to perform quantitative analysis of immunohistochemistry confocal microscopy images acquired from human and animal retinal tissue samples. The expected outcomes were statistical testing of our hypotheses regarding the retinal manifestations of Alzheimer’s disease, for example increased amyloid beta load. Amyloid beta (Ab) in the brain is a hallmark of Alzheimer’s disease…

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Stress-related cytoplasmic TDP-43 aggregation and its role in neuronal apoptosis in a cell culture model of PGRN deficiency Alzheimer Disease

ABSTRACT Neurodegeneration occurs in many neurological disorders such as and Alzheimer’s disease (AD). Two proteins named progranulin (PGRN) and TDP-43 have been found to be associated with Alzheimer’s disease (AD). We have established a cell culture model that recapitulates many aspects of human PGRN deficiency and leads to changes in TDP-43 as observed in AD…

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Together, we can find a cure for Alzheimer disease.

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