100% committed to ending dementia. For good.

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All in to end Alzheimer disease.

CLEAR is the only Canadian foundation that directs 100% of funds raised to promising scientific research into the cause, prevention, and treatment of Alzheimer disease and other dementias.

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Because it’s clear: the only path to a cure is more research.

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650K+

people living with dementia in Canada

Even more alarmingly, by 2031 this number is expected to exceed 1 million.

40

research projects funded by CLEAR

Each of these projects has contributed to our collective understanding of dementia.

8th

leading cause of death in Canada

Every year, over 6,000 Canadians die from the disease. That’s 16 loved ones lost each day.

$15M+

of funding provided to researchers

We will keep funding promising research until we have the cure the world has been waiting for.

Past & Present Research

The role of smooth muscle cell metabolism of amyloid beta in cerebral amyloid angiopathy

ABSTRACT The research goal is to understand how the harmful protein, amyloid beta, deposits in blood vessels of the brain, leading to dementia. A key change in the brains of individuals with Alzheimer’s and other forms of dementia is the accumulation of amyloid beta in arteries, in regions normally occupied by smooth muscle cells, the…

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Neurally-produced estradiol enhances the neuroprotective actions of insulin

ABSTRACT Estradiol enhances insulin production and response in the pancreas. However, the effects of estradiol in the brain have never been confirmed. Yet when expressed together in the hippocampus (a brain structure critically involved in memory), estradiol and insulin promote neuron growth and survival as well as synapse formation and maintenance. Dr. Mehran tested the…

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Assessment of melanotransferrin as an Alzheimer’s disease biomarker

ABSTRACT Millions people worldwide are currently afflicted with Alzheimer’s disease (AD). In the absence of a complete understanding of the disease, therapeutic trials have been unsuccessful and there still remains no cure. Biomarkers that can reliably detect AD at the earliest possible stage are essential for disease monitoring and drug therapy. The development of a…

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Non-invasive imaging of Alzheimer Disease biomarkers in the brain and eye

ABSTRACT Age related neurodegenerative diseases such as Alzheimer’s Disease (AD) affect ~500,000 Canadians, and the economic burden of dementia was $15 billion in 2008. Early diagnosis and novel therapies are needed to improve the quality of life of affected individuals, and to reduce costs to the Canadian health care system. However, screening for irreversible hallmarks…

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Together, we can find a cure for Alzheimer disease.

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