100% committed to ending dementia. For good.

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All in to end Alzheimer disease.

CLEAR is the only Canadian foundation that directs 100% of funds raised to promising scientific research into the cause, prevention, and treatment of Alzheimer disease and other dementias.

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Because it’s clear: the only path to a cure is more research.

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650K+

people living with dementia in Canada

Even more alarmingly, by 2031 this number is expected to exceed 1 million.

40

research projects funded by CLEAR

Each of these projects has contributed to our collective understanding of dementia.

8th

leading cause of death in Canada

Every year, over 6,000 Canadians die from the disease. That’s 16 loved ones lost each day.

$15M+

of funding provided to researchers

We will keep funding promising research until we have the cure the world has been waiting for.

Past & Present Research

The mechanism and significance of the synaptogenic activity of amyloid precursor protein

ABSTRACT Amyloid Precursor Protein (APP) is a cell surface protein that has been mostly studied in the context of Alzheimer’s disease. Much about its normal function remains unknown. APP can cause connections to form between brain cells by an unknown mechanism. We believe this happens through an interaction with synaptic organizing proteins (organizers). This project…

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Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology

ABSTRACT A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the primary cause of brain cell death in Alzheimer’s disease. We have identified an A-beta oligomer-specific targeting site, which exclusively detects A-beta oligomers in the brains…

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Characterizing Dementia due to mixed Alzheimer and Vascular Pathology

ABSTRACT Over half a million people in Canada suffer from dementia today, costing the Canadian society over $15 billion dollars annually. Alzheimer disease and stroke are the first and second most common causes of dementia in the elderly. These two diseases often occur together in the brain, making it difficult to know which disease is…

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Validation of Connexins and Pannexins as a target for Alzheimer’s Disease

ABSTRACT Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. There are currently no successful treatments, making the discovery of effective therapeutic interventions critical. The brain contains billions of neurons, and substantially more non-neuronal cells called glia; the major ones relevant to this proposal are astrocytes. While…

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